Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's ...

Massage might help your brain flow regain its mojo. On June 4 in Nature, researchers led by Gou Young Koh at the Institute for Basic Science in Daejeon, South Korea, mapped the labyrinth of lymphatics ...

Brain & Brain PET 2025 01 &#x2013 04 June 2025Seoul, South Korea View conference website Gordon Research Conference: Neurotrophic Factor Function in Development Health and Disease 01 &#x2013 06 June ...

Leucine-rich repeat kinase 2 encodes a large, complex protein containing a kinase, a GTPase, and multiple protein-protein interaction domains. The interplay of its enzymatic kinase and signaling ...

Glymphatic clearance, which relies on a network of astrocytic endfeet arranged along vessels of the cerebrovasculature, has been implicated in AD, though it is not without controversy. Perivascular ...

Other Phenotypes Premature death, attributed to hindbrain tauopathy, generally occurs between eight and 12 months (Dutschmann et al., 2010). Premature death is preceded by weight loss, hyperkyphosis, ...

To find out, Parhizkar gave lemborexant to P301S/E4 mice, which express human mutant tau along with human ApoE4, a risk factor for AD (Apr 2017 conference news). In this model, tau tangles begin to ...

What’s more, the annexin shrank these neurites, as seen by a reduction in the amount of LAMP1, a lysosomal protein that packs into these membrane swellings. The size or number of amyloid plaques ...

In a healthy brain, border-associated macrophages within the dura mater and choroid plexus are replaced by circulating monocytes, while those in the leptomeninges and perivascular spaces, and also ...

Findings The presence of three copies of chromosome 21, which harbors the amyloid precursor protein (APP) gene, is the most common genetic cause of Alzheimer’s disease. Carriers of this alteration ...

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