When conceiving this biographical account, I realized that many of my experiences have been of a dialectic nature, in the sense of a Hegelian ‘thesis–antithesis– synthesis’: from the development of my ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Phosphorylation is a key post-translational ...

Major histocompatibility complex class II (MHC II) molecules are targeted to endocytic compartments, known as MIIC, by the invariant chain (Ii) that is degraded upon arrival in these compartments. MHC ...

Figure 6C, the same pictures were used for different genotypes, i.e. kno1 RMI1-RFP and agt5 RMI1-RFP; the pictures are ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Transient receptor potential vanilloid (TRPV) ...

The fate of normal intestinal stem cells is determined through neutral competition. This study shows that when oncogenic K‐Ras mutations arise, biased stem cell competition leads to a drift towards ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In order to address this outstanding ...

The death of cardiac myocytes diminishes the heart's pump function and is a major cause of heart failure, one of the dominant causes of death worldwide. Other than transplantation, there are no ...

Together with the NS5 polymerase, the NS3 helicase has a pivotal function in flavivirus RNA replication and constitutes an important drug target. We captured the dengue virus NS3 helicase at several ...

The crystal structure of a fully active form of human protein kinase CK2 (casein kinase 2) consisting of two C‐terminally truncated catalytic and two regulatory subunits has been determined at 3.1 Å ...

Histone deacetylases (HDACs) play important roles in transcriptional regulation and pathogenesis of cancer. Thus, HDAC inhibitors are candidate drugs for differentiation therapy of cancer. Here, we ...

Global hepatic DNA methylation change has been linked to human patients with metabolic dysfunction-associated steatotic liver disease (MASLD). DNA demethylation is regulated by the TET family proteins ...