The painkilling, antipyretic, and antiinflammatory properties of aspirin have been known for centuries. The understanding that aspirin targets cyclooxygenase-1 (COX-1) (also known as ...

The results of the KEYNOTE-689 trial reported by Uppaluri et al. (July 3 issue)1 are highly important. The addition of perioperative pembrolizumab has become the new standard of ...

Idiopathic normal-pressure hydrocephalus is a neurologic disorder characterized by impaired gait, balance, cognition, and ...

The planned implementation of Medicaid work requirements provides an opportunity to obtain longitudinal data to guide ...

Tobacco use kills more than 7 million people worldwide each year, including 1.3 million who die from the effects of exposure to secondhand smoke.1 As a major contributor to cancer, cardiovascular ...

There is an urgent need for low- and middle-income countries to ensure equitable, affordable, and sustained access to tobacco-cessation medications at scale.

Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey Clinical Medical Research Award for their roles in developing treatments for cystic fibrosis.

HCM is the most common inherited heart disease worldwide and is associated with considerable disease-related morbidity. A substantial subpopulation of patients with HCM have disease characterized by a ...

Dr. Leigh H. Simmons: A 93-year-old woman was evaluated by her primary care physician because of dyspnea. The patient had been in her usual state of health, which included being independent with ...

In 2019, seven county correctional facilities (jails) in Massachusetts initiated pilot programs to provide all Food and Drug Administration–approved medications for opioid use disorder (MOUD). This ...

We randomly assigned, in a 2:2:1 ratio, participants with previously untreated EGFR -mutated (exon 19 deletion or L858R substitution), locally advanced or metastatic NSCLC to receive ...

China has recently emerged as an important player in new drug development — a field traditionally dominated by the United States and Europe. This shift has implications for global access to new ...