2022年2月21日 · The critical link between metabolism and immunity is highlighted by the findings that cellular metabolism affects immune cell state and fate, and contributes to infectious disease,...

2024年10月9日 · In this review, we focus on immune cells to introduce their metabolic pathways and metabolic reprogramming, and summarize how these metabolic pathways affect immune effects in the context of...

Metabolism regulates immune cell activation. Glycolytic metabolism in immune cells typically leads to activation of an effector phenotype (eg, effector T, M1-like macrophages, DC, NK, and B cells), whereas oxidative metabolism of substrates such as fatty acids (lipid) and amino acids including glutamine leads to a regulatory or memory phenotype.

2019年1月2日 · Here, we review how metabolism guides immune cell activation and differentiation to distinct cellular states, and how differential regulation of metabolism allows for context-dependent...

2017年3月7日 · The microbiome interacts with the host immune system to regulate metabolism by various mechanisms: direct physical contact, production of metabolites, and shedding of structural components. These affect metabolic homeostasis by local mucosal immune modulation and by remote alteration of metabolic organs, such as adipose tissue, muscle, and the ...

Here, we discuss these findings and provide a general framework for understanding how metabolism fuels and regulates the maturation of immune responses. A better understanding of the metabolic checkpoints that control these transitions might provide new insights for modulating immunity in infection, cancer, or inflammatory disorders.

In this review, we explore the interactions between immune cells and the tissue environments they inhabit, how these impinge on their metabolism, how their metabolism instructs their function and fate, and how these relationships contribute to tissue homeostasis and disease pathology.

2016年1月1日 · This review article describes the distinct metabolic signatures of key immune cells, explains how these metabolic setups facilitate immune function, and discusses the emerging evidence that intracellular metabolism has an integral role in controlling immune responses.

10.1.1 Metabolism and the Immune System: A Brief Overview. Before exploring the interplay between metabolism and immunity, the key players will be discussed independently first. Metabolism is a set of biochemical reactions that enable cellular function and sustain life. It can be dichotomized into catabolism and anabolism (Fig. 10.1 ...

The microbiome interacts with the host immune system to regulate metabolism by various mechanisms: direct physical contact, production of metabolites, and shedding of structural components. These affect metabolic homeostasis by local mucosal immune modulation and by remote alteration of metabolic organs, such as adipose tissue, muscle, and the ...