The isthmic organizer, or isthmus organizer, also known as the midbrain−hindbrain boundary (MHB), is a secondary organizer region that develops at the junction of the midbrain and metencephalon (embryonic hindbrain). [1] The MHB expresses signaling molecules that regulate the differentiation and patterning of the adjacent neuroepithelium.

2001年2月1日 · Local signalling centres are important in patterning the neural axis. The isthmic organizer (IsO), which lies at the junction between the midbrain and hindbrain, is one of these signalling...

The isthmic organizer is a signaling center that secretes fibroblast growth factor 8 (FGF8), a key molecule required for orchestrating multiple stages of cerebellar development (Crossley et al., 1996; Martinez et al., 1999), with an early role in maintaining the posterior border of Otx2 expression (Foucher et al., 2006).

The isthmic organizer (IsO), a transient embryonic signaling center that develops at the boundary separating the midbrain and the hindbrain, is central to this critical process (Figure 22.4; reviewed in Nakamura et al., 2008; Wurst and Bally-Cuif, 2001). The secreted molecule fibroblast growth factor 8 (Fgf8), specifically expressed at the IsO ...

Two organizing centres operate at long-range distances within the anterior neural plate to pattern the forebrain, midbrain and hindbrain. Important progress has been made in understanding the formation and function of one of these organizing centres, …

2022年3月24日 · Although some isthmic neurons migrate into the contiguous neuromeres, the caudal midbrain and r1, these findings do not question the existence of lineage restriction in r0 (Watson et al., 2017). FGF8 is the molecule responsible for the isthmic organizer properties of …

Recent work has shown that two transcription factors, Otx2 and Gbx2, are instrumental in positioning the isthmic organizer at the midbrain–hindbrain boundary. on histological and anatomical studies, it has been suggested that cell type is determined by genetic elements1.

2023年6月5日 · It is argued that the peculiar molecular and structural profile of the preisthmus is due to its position as rostrally adjacent to the isthmic organizer, where high levels of both FGF8 and WNT1 morphogens must exist at early embryonic stages. Isthmic patterning of the midbrain is discussed in this context.

2016年3月3日 · The isthmic organizer (IsO) is a signaling center that specifies the correct and distinct embryonic development of the dopaminergic midbrain and serotonergic hindbrain. The IsO is a linear boundary between the two brain regions, emerging at around embryonic day 7-8 of murine embryonic development, that shapes its surroundings through the ...

2003年11月15日 · During vertebrate development, an organizing signaling center, the isthmic organizer, forms at the boundary between the midbrain and hindbrain. This organizer locally controls growth and patterning along the anteroposterior axis of the neural tube.